For Research

MUSE can model anything — cells, neurons, amoebae, flocks of birds. But we specialize in modeling people. When you model people with real internal states in real environments, you get data that matters.

Why Simulation Now

Research is hitting a wall that more experiments won't solve.

Across biology, behavioral science, and biomedicine, the dominant methodology is unchanged from fifty years ago: pose a narrow hypothesis, design an experiment, collect data, run statistics, publish. Then repeat with a minor variation. Each cycle takes months to years. Each cycle produces a small increment of knowledge tied to a specific experimental paradigm. Replication crises, variable results, and slow progress aren't accidents — they're what happens when you try to map a vast hypothesis space one experiment at a time.

The problem isn't experimental rigor. The problem is that the hypothesis space is too large to test exhaustively, and the methodology has no efficient way to narrow it before running experiments. So researchers test what's familiar — the same EEG bands, the same behavioral paradigms, the same statistical contrasts — because exploring beyond the familiar is too expensive to attempt.

The Methodology That Works

The fields making the fastest progress today have already changed how they work. Computational biology, climate science, and parts of physics now follow a different loop:

  1. Modeling and simulation for hypothesis generation. Use mechanistic models and simulation to explore the space of plausible mechanisms. Identify which hypotheses are biologically defensible and worth testing.
  2. ML interpretability and pattern discovery in existing data. Most datasets contain far more signal than any single hypothesis test extracts. Modern ML tools can surface patterns that point to new hypotheses without collecting new data.
  3. Naturalistic data collection via sensors at scale. When new data is needed, collect it in the environments where the phenomenon actually occurs — not in artificial lab conditions designed for one narrow contrast.
  4. Targeted experiments only where validation is genuinely necessary. Reserve in-lab experiments for the small number of cases where prior work has produced specific, falsifiable predictions worth testing carefully.

The result is faster discovery, broader exploration, and experiments that matter more because each one is sharper. The fields that have adopted this loop are outcompeting the fields that haven't, on rate of progress per dollar and per year.

What MUSE Enables

MUSE is infrastructure for this methodology — not a faster version of the existing experimental pipeline, but the substrate for a different one.

Rapid, Massive-Scale Exploration

Run parameter sweeps that would take months on traditional infrastructure in hours. Explore hypothesis spaces that are currently inaccessible.

Hypothesis Generation

Identify which mechanisms are biologically plausible, which combinations produce the patterns observed in real data, which interventions are worth testing in the lab.

Composable Models Across Domains

Combine mechanistic models of biological systems with agent-based dynamics and neural surrogates in a single runtime. Most real questions span scales and domains that existing tools cannot bridge.

Derisking Before Experiments

Run thousands of simulated experiments in the time it takes to run one real one. Identify which experimental designs are sensitive to the effects you care about before committing to human subjects research.

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Research Domains

MUSE has been applied to or is actively being developed for:

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Active Grant Programs

Gothic Grandma is actively pursuing federal grant funding across three research domains.

IES — Literacy

Using emergent simulation to build reading engagement through agency. Children read more when they have meaningful control over a world that responds.

NICHD — Neurodivergence

Simulation environments for social situation practice and neurodivergence training — worlds that accommodate different processing styles naturally.

NIAID — Epidemiology

Agent-based epidemiological modeling with real behavioral systems. Not network models — full entity simulation with internal immune, social, and behavioral states.

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How Researchers Access MUSE

Research access is provided through a restricted GLYPH license. Researchers can configure starting parameters, define experimental conditions, and run FONT headless at scale. Results are exported as curated datasets.

The simulation architecture stays proprietary — researchers work with the engine, not its internals. This keeps the platform consistent across research groups and protects the investment that makes the platform possible.

As the platform matures, we are building toward a funded research fellowship program — direct awards to graduate students and early-career researchers doing work with MUSE in exchange for co-publication and citation. That program is aspirational for now, but it reflects where we intend to go.

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Why MUSE Over Existing ABM Tools

Tools like NetLogo, Mesa, MASON, and FLAME GPU 2 are valuable and have long track records. MUSE offers different trade-offs.

GPU Scale

Millions of entities with full internal states. No CUDA required.

Composable Behaviors

Behaviors are modular, mix-and-match across entity types.

Researcher Workbench

GLYPH provides a full R&D environment — configure, run, analyze, export.

Scientific Grounding

Systems derived from neuroscience, behavioral science, and cognitive science literature.

Apply for research access →